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The recommended starting dose is 2 milligrams. Because the result of Zanaflex comes to a head at around 1 to 2 hours post-dose and dissipates between 3 to 6 hrs post-dose, therapy can be repeated at 6 to 8 hr intervals, as needed, to a max of three dosages in 24 hours.





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Dosage can be progressively enhanced by 2 milligrams to 4 mg at each dosage, regarding 1 to 4 days between dosage rises, till a satisfactory reduction of muscular tissue tone is accomplished. The overall everyday dosage needs to not surpass 36 milligrams. Single dosages more than 16 milligrams have not been studied.





Zanaflex should be used regarding caution in people regarding kidney deficiency (creatinine clearance < 25 mL/min), as clearance is decreased by even more compared to 50 %. In these individuals, throughout titration, the specific dosages should be reduced. If higher dosages are called for, specific doses rather compared to application frequency need to be increased [ see Precautions and precautions (5.





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Zanaflex needs to be utilized regarding care in people with any hepatic disability. In these individuals, during titration, the specific dosages ought to be decreased. Individual doses instead than application regularity must be increased if higher doses are called for. Monitoring of aminotransferase degrees is suggested for baseline and 1 month after maximum dose is attained, or if hepatic injury is believed. [view Use in Specific Populations (8.

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